Good health policies and strategies are important, but not sufficient. They must be put into practice. Despite a growing body of literature on policy implementation, understanding how best to implement policies remains a challenge in realworld settings. The aim of this paper is to demystify “policy implementation” and provide user-friendly advice on translating policies into action. To do so, the paper presents experiences and lessons learned from the USAID | Health Policy Initiative, Task Order 1, organized around the project’s Policy-to-Action Framework. The framework recognizes that moving from policy to action is a dynamic, iterative process that unfolds differently in different contexts. In practice, the interdependent elements must be mixed together—sometimes out of sequence, often many elements at once, and over and over again—to achieve effective policy implementation. Also, while implementation involves elements that should be carried out in a more methodical way, bringing all of the elements together is indeed an art. It requires understanding policy issues, the context, and stakeholders; anticipating potential roadblocks; seizing windows of opportunity; and building and sustaining commitment, capacity, and resources over time.